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KMID : 0545120160260122138
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Journal of Microbiology and Biotechnology
2016 Volume.26 No. 12 p.2138 ~ p.2140
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Inhibitory Components from Glycosmis stenocarpa on Pepper Mild Mottle Virus
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Kim Jang-Hoon
Yoon Ju-Yeon
Kwon Sun-Jung
Cho In-Sook
Cuong Nguyen Manh
Choi Seung-Kook
Kim Young-Ho
Choi Gug-Seoun
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Abstract
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The goal of this study was to identify a source of natural plant compounds with inhibitory activity against pepper mild mottle virus (PMMoV). We showed, using a half-leaf assay, that murrayafoline-A (1) and isomahanine (2) isolated from the aerial parts of Glycosmis stenocarpa have inhibitory activity against PMMoV through curative, inactivation, and protection effects. Using a leaf-disk assay, we confirmed that 2 inhibited virus replication in Nicotiana benthamiana. Using electron microscopy, we found that a mixture of the virus with 2 resulted in damage to the rod-shaped virus.
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KEYWORD
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Pepper mild mottle virus, Glycosmis stenocarpa, isomahanine, electron miscroscopy, antiviral agent
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